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Vitamin B12 (cobalamin) is a water-soluble vitamin

Stage 1: Depleted Stores (Often Asymptomatic) Liver B12 stores decline

Manifestations include tingling and numb extremities, motor disturbances such as abnormalities of gait, and cognitive changes that range from memory loss and depression to frank dementia, with or without mood changes (Goodman & Salt, 1990)