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[11] TMG can help replenish methyl groups and facilitate the clearance of nicotinamide, theoretically reducing the buildup of by-products that could cause fatigue or headaches in some individuals

I published a patient information sheet on it (just before I created my website), and several of my patients tried it with modest effects

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However, the rate of return to control level is much slower

Those interested in similar injectable medications can explore options like Ozempic that are currently accessible