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Essential protective roles of reactive astrocytes in traumatic brain injury

2023;133:e164508

Br Med J (Clin Res Ed), 1985

Assuming that there is enough extracellular H 2 O 2 present at sites of infection, NET-bound MPO could generate reactive hypohalous acids in the immediate vicinity to trapped pathogens and thus effect their killing

It is noteworthy that sublethal permeabilization of the mitochondrial outer membrane induces mitophagy, which serves to limit the release of mtDNA and ROS by facilitating the degradation of dysfunctional mitochondria via lysosomal pathways