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The study by Honda et al., conducted in 2017, was an open-label, single-arm, multicentre pilot study that evaluated the therapeutic effect of oral glutathione administration (300 mg/day) in patients with NAFLD through the evolution of biochemical indices (ALT) and liver fat levels assessed by VCTE (79)

Even though developing a vaccine against GPNMB positive cells seems to be beneficial, the challenge remains to only deplete cells with the highest expression of the protein but not the cells expressing it at a physiological level 63

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In in the NS group, antioxidant supplementation over three months led to a greater reduction in oxidative stress and improved semen quality, suggesting a potential benefit of targeted antioxidant therapy in mitigating NSW-related oxidative damage and infertility issues 84

In early IDD, the number of NP cells decreases, the activity of NP cells is inhibited, and the secretion of proteoglycans decreases