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Jarhahzadeh et al

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Black R (2016) Development, historical use and properties of chemical warfare agents

3.4.3 Behavioural factors The bile acid sequestrants cholestyramine, colestipol and colesevelam decrease the T4 concentration probably via the augmented enterohepatic recycling of T4 [120, 121], although cholestyramine additionally forms a complex with T4 in the stomach and thus increases the amount of T4 excreted in the feces [122]

Preclinical and early-phase clinical investigations have examined its impact on body weight and fat mass: In obese animal models, AOD9604 has been associated with reductions in body weight and fat mass over defined treatment periods