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p = 0.005), again with high heterogeneity (I 2 = 89%)

Patients with androgenetic alopecia need a structured hair restoration protocol, exosomes, PRP, or medical management, with GHK-Cu as a complementary add-on, not the primary treatment

When NNMT is overactive, it consumes excess NAD+, leaving less available for these critical processes

Common reasons for deficiency include: Low intake particularly diets low in whole grains, legumes, leafy greens or animal products Gut health issues like low stomach acid, SIBO, coeliac disease, IBD, or other factors affecting absorption Medications such as the contraceptive pill, metformin or antacids, which can deplete B vitamins Chronic stress increases demand for certain b vitamins, including B5 and B6 Vegan or vegetarian diets higher risk of B12 deficiency, which can be corrected through supplementation Genetic reasons some mutations on certain genes can increase a persons need for B vitamins This is why I always recommend testing before supplementing