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Mutational analysis revealed key residues (R63, F64, W65, H71, R72, G73, R80) crucial for enzyme function, despite not directly binding the substrate

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Ophardt CE

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Improving mitochondrial flux isn't just about weight loss

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Interestingly rats given p53 inhibitors and amifostine did not have improved survival compared to controls, suggesting amifostine acts (at least in part) via a p53 dependent mechanism [55]

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