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Description

These acylcarnitines can be exported from the mitochondria and cell, preventing the toxic accumulation of acyl-CoA intermediates that inhibit key metabolic enzymes

Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2

No substantial protocol amendments affecting eligibility criteria, outcomes, or analyses were made after trial initiation

However, the relationships between mitochondria and synapses, and the role of mitochondria in the pathogenic mechanisms of these syndromes have yet to be established