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Although clinical findings have revealed that osteoarthritic phenotypes are one of the common complications in patients with hemophilia (Braner, 2018), related pathogenesis and mechanisms of disease progression are yet to be fully understood

The GCLM subunit has no enzymatic activity but has an important regulatory function increasing the efficiency of the GCLC subunit

Numerous investigations have suggested that disruption of the GSH system is a critical element in the pathogenesis of myocardial injury

TDP-43 aggregates similarly compromise mitochondrial function, causing fragmentation and bioenergetic failure as organelles become trapped in the soma rather than distributing to distal motor neurone processes [101]

Prophylactic treatment of migraine with beta-blockers and riboflavin: differential effects on the intensity dependence of auditory evoked cortical potentials