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Importantly, the first committed step of the pathway, catalyzed by glucose-6-phosphate dehydrogenase (G6PD), is inhibited by NADPH [57]

At the same time, GSH is oxidized to GSH disulfide, which is then decreased back to GSH by nicotinamide adenine dinucleotide phosphate (NADPH)-dependent on GSH reductase to enter the next cycle

Glob Chang Biol 2:527545 Shreve SM, Kelty JD, Lee RE (2004) Preservation of reproductive behaviors during modest cooling: rapid cold-hardening fine-tunes organismal response