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It is amphiphilic and due to this property is readily taken up in tissues, including the nervous system, as it can cross the blood-brain central barrier [17,18]

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Similar to what was observed in human patients, the meningococcus colonized capillaries, venules, and arterioles with the progressive accumulation of recruited neutrophils in the humanized mouse model

Specifically, upregulation of PHGDH activity through PHGDH amplification or overexpression is reported in various cancer cells [71] and is closely associated with tumor growth, metastasis, chemoresistance, and poor patient survival [72]

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