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Drug Metab Rev 115 Jia ZL et al (2019) Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway

2b, Extended Data Fig

Recent evidence shows that metastatic tumors are more transcriptomically like their target tissues, suggesting their ability to mimic organ-specific microenvironmental components to gain support at metastatic sites [60]

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These safety assessments must unequivocally demonstrate that genetically modified organisms cannot persist in the environment, lack transferable antibiotic resistance markers, and are incapable of disseminating any deleterious genetic material to other microbiota (99)