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Overuse of stimulants : Excessive use of stimulants like caffeine can exacerbate HPA axis dysfunction, while smoking and alcohol can worsen inflammation, interfere with sleep, and have other negative effects

The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high fat diet-induced obesity

Upon entering plant cells, NPs can induce ROS generation, which in turn activates transmembrane ion channels, antioxidant defense systems, and mitogen-activated protein kinases (MAPKs) 103,104

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