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After the original oxycodone COM patent expired, Purdue listed formulation patents covering the abuse-deterrent matrix that extended Orange Book protection and created a new barrier to generic entry requiring bioequivalence to the reformulated product, not the original

doi: 10.3390/microorganisms8040483

Molecular docking predicts interactions with bacterial enzymes, while physicochemical modeling estimates permeability across ocular barriers (Singh and Shukla, 2012)