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International Journal of Molecular Sciences, 21 (19), 7157

A clinical study found that the UPR genes of the ER, including IREI, ATF6, XBP1, BIP, and CHOP, and the UPR genes of the mitochondria, including HSP10, HSP60, CLPP, and HSP40, were increased in granulosa cells of women with PCOS [169]

Future studies are warranted to identify the mechanism underlying this dual inhibition as well as potential targets for treating pathological conditions associated with both necroptosis and ferroptosis