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The reduction in NO levels aligned with previous studies on natural extracts rich in polyphenols and flavonoids, which have been shown to inhibit iNOS expression and mitigate inflammation through the downregulation of NF-B signaling 73,74

In addition, the results gathered in this study are of particular importance especially as more applications for synthetic vitamin-B 12 derivatives continue to be realized

tomentosa extracts, active compounds that present anti-neoplastic effects are also separated, as well as constitute evidence of the importance of the oxidative stress modulation as part of the action mechanisms of this plant

At present, several effective anti-tuberculosis drugs, such as isoniazid [55], ethionamide, thiacetazone, and delamanid, have been shown to inhibit the biosynthesis of MAs