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HoferTMarzettiEXuJSeoAGulecSKnutsonMet alIncreased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy

Therefore, although both nonenzymatic and enzymatic succinylations occur on GCLC, the latter mediated by P300, in cooperation with SIRT2, may play a major role in dynamically modulating the succinylation level of GCLC under stress condition