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Despite progress in neural repair research 3 , effective axonal regeneration and remyelination remain difficult to achieve, representing a major barrier to functional recovery

The Neh6 domain, which is a serine-rich region, contributes to regulate NRF2 stability and mediates the interaction with a third negative regulator, -transducin repeat-containing protein (-TrCP), through its DSGIS (Aspartic acid-Serine-Glycine-Isoleucine-Serine) and DSAPGS (Aspartic acid-Serine-Alanine-Proline-Glycine-Serine) motifs not recognized by KEAP1

This suggested that CXCL10 is predominant over other cytokines to be a potential novel marker indicating the NRTP-induced early damage on ovaries

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We used age-matched male mice in all animal experiments to avoid possible shielding of estrogen on heart failure