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BDNF levels, crucial in neural plasticity, were decreased under IH conditions (Xie et al., 2010)

Funding This work was supported by Qatar University Internal Grant, under QUUG-CPH\ 2017-4

10.1016/j.ccell.2025.03.031 81 LevineB.KroemerG

How do they work in synergy

For other cancer entities including bladder cancer and oral cavity carcinoma, a downregulation of ODC1 by DNA hypermethylation and subsequently global demethylation has been reported [70,71]