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Importantly, the intracellular Cu concentration is kept at a relatively low range, and moderate increases can cause cytotoxicity and even lead to cell death

Besides upregulating the expression of flagellar components, LCA itself is highly hydrophobic and therefore might also physically interact with flagella, potentially changing how the flagella interact with each other, with other bacterial cell surface components, and/or with the host mucosa

Dysregulation of these enzymes significantly impacts GSH homeostasis, leading to pathological changes