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AA homozygotes: Normal

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

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24 These mutations serve as key molecular discriminators between glioma subtypes and are highly prevalent in lower-grade diffuse gliomas (WHO grades IIIII) and secondary GBMs 25 but are largely absent in primary GBMs, which are predominantly IDH wild-type

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase to Regulate Proteasomal Degradation of Nrf2