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Taking postmenopausal osteoporosis as an example, estrogen deficiency induces M1 polarization of macrophages by activating the Toll-like receptor 4 (TLR4)/Myeloid Differentiation Factor 88 (MyD88) signaling pathway

When the homeostatic balance of copper ion levels is disrupted, such as through excess copper ions, this imbalance can trigger cellular toxicity and induce cell death via various pathways (15)