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A nonnative isomer of some peptide groups can disrupt the conformational folding significantly, either slowing it or preventing it from even occurring until the native isomer is reached

Intranasal treatment of salvinorin A, a highly selective non-opioid kappa opioid receptor agonist, reduced neuroinflammation and BBB permeability in transient MCAO mice (Misilimu et al., 2022)

Depending on the specific context, reactive gliosis can be either beneficialpromoting improved functional outcomesor detrimental, leading to maladaptive impairments or neurodegeneration 377