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3.4 Precision-orchestrated therapeutic architectures for uremic toxin neutralization A constellation of pharmacological interventions orchestrates colonic uremic toxin metabolism through exquisitely distinct mechanistic pathways: the synergistic convergence of folic acid and methylcobalamin administration catalyzes homocysteine metabolic recalibration, systematically attenuating serum asymmetric dimethylarginine (ADMA) concentrationsa formidable mediator of endothelial dysfunction and cardiovascular pathophysiology (Angelini et al., 2021

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These include reduced nuclear factor-kappa B (NF-B) activation, decreased oxidative stress, and improved endothelial function

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