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Organophosphate exposure is now being linked to lower IQ, and conditions such as autism and ADHD

Because PPIs are sensitive to degradation by strong acid, they have a limited half life within the acidic canaliculi, which can lead to less than maximal effect during the first ~3 days of therapy, and inadequate elevation of gastric pH without repetitive dosing

NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1 stabilization by inhibiting prolyl hydroxylases activity

These changes may contribute to metabolic improvements independently of weight loss