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Interestingly, although previous evidence has suggested that AD patients generally demonstrate progressive deterioration in brain perfusion and clinical symptoms, a recent SPECT study depicted an increase in the perfusion of the precuneus in AD patients after the administration of ALC, along with a lack of further deterioration of cognitive and neuropsychiatric symptoms [52]

Jos HJ, Berenice SG, Cecilia VR

pruriens seeds used at a dose of 500 mg/kg reduced plasma glucose levels

Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharidestimulated periodontitis in vitro and in vivo

however, some studies show that hypoxia inhibits the viability and proliferation of AD-MSCs and NP-MSCs while promoting chondrogenic differentiation ( Other MSCs such as placenta-derived (PMSCs), annulus fibrosus-derived (AF-MSCs), and peripheral blood-derived (PB-MSCs) also show enhanced proliferation, migration, or stemness under hypoxia (Ni et al., 2014