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By synthesizing a molecule that could permeate the cell membrane and selectively inhibit NNMT, researchers discovered they could fundamentally alter the metabolic profile of the cell

Nine subjects were on anti-hypertensive medications

doi: 10.1161/01.ATV.0000251608.09329.9a 375 BirkenfeldALShulmanGI

2.8 Future directions A surprising group of pharmacological agents that are currently widely used in the treatment of psychiatric conditions have the property of negatively modulating pkc and in particular, prkcg (Table 1)