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Furthermore, constant 1/ 2 values for all E170X mutants (in contrast to K105X mutants) suggest that the mutation of Glu170 had no effect on a rate-limiting reduction by GSH (Fig

doi: 10.1053/j.gastro.2006.11.039 82 CoelhoAMFioramontiJBuenoL

Yuan J, Luo RZ, Fujii S, Wang L, Hu W, Andreeff M , Pan Y, Kadota M, Oshimura M, Sahin AA, Issa JP, Bast RC, Jr, Yu Y

Final Results of RTOG 0246: A Phase II Study of Selective Surgical Resection for Locoregionally Advanced Esophageal Cancer Treated With Paclitaxel Based Chemoradiation Regimen

It plays a role in the angiogenesis and vasculogenesis processes, where it regulates the expression of key molecules on the cell surface to modulate cell adhesion and motility 42