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Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue

(4) Inhibition of the electron transport chain: -syn aggregation impedes ATP production and increases the generation of ROS by diminishing the activity of mitochondrial complex I (Indrieri et al., 2020

This biochemical profile correlates strongly with worse clinical progression, higher inflammatory markers, and the onset of severe neurological sequelae