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Studies have shown that GHK-Cu at concentrations of 0.01, 1, and 100 nM significantly increased the production of elastin and collagen in human dermal fibroblasts, which are the cells responsible for building skin structure

PMOS-related insulin resistance causes hyperinsulinaemia chronically elevated insulin that overstimulates androgen production in the ovaries

Ann Gastroenterol (2015) 28:2039

It's the difference between maintaining collagen synthesis signaling throughout the remodeling cycle versus spiking copper-GHK plasma levels for 36 hours and then losing the signal entirely

There are probably a few reasons causing this post-injection pain