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Transporter-Mediated Nanocarrier Delivery Approach The transporter-mediated nanocarrier delivery strategy is based on the incorporation of transporter substrates on the nanocarrier surface, which bind to the transporter protein on the cellular membrane and trigger the internalization process (80)

Also preferred is a composition of matter comprising isolated nucleic acid molecules wherein the nucleotide sequences of said nucleic acid molecules comprise a panel of at least two nucleotide sequences, wherein at least one sequence in said panel is at least 95% identical to a sequence of at least 50 contiguous nucleotides in a sequence selected from the group consisting of: a nucleotide sequence of SEQ ID NO:1 wherein X is any integer as defined in Table I

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The transport kinetic parameters, such as affinity (K m ) and transport capacity (V max ), are essential for understanding the capability of the (pro)drugs to utilize the transporter and planning pharmacokinetics studies

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