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By histological analyses of biopsies, it was re-confirmed that the use of topically applied Cu-GHK products intensified skin thickness in the range of the epidermis and dermis, and that keratinocyte proliferation of the skin was greatly stimulated [40]

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284,285,286 Moreover phase I clinical trial has shown that the combination of DSFCu and temozolomide has an acceptable safety profile and increases progression-free survival in patients with glioblastoma 287 (Table 1)