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and also watershed waters (Esteban et al

Studies on erythropoietin (EPO), a glycoprotein hormone required for the proliferation and differentiation of erythroid cells, demonstrated that EPO production is enhanced under hypoxic conditions [52, 53, 59, 61, 64, 65]

A scaling factor greater than one indicates that the model fingerprint needs to be scaled up to best match the observations (i.e., the model underestimates the magnitude of the trend), and a scaling factor less than one means that the model fingerprint needs to be scaled down to best match the observations