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Zheng R, Blanchard JS

Based primarily on mouse studies, it is proposed that the GATA1-FOG1 complex promotes human erythropoiesis by recruiting and binding with at least two gene expression-regulating complexes, Mi-2/NuRD complex (a chromatin remodeler) and CTBP1 (a histone deacetylase) and three gene expression-regulating proteins, SET8 (a GATA1-inhibiting histone methyltransferase), BRG1 (a transcription activator), and Mediator (a transcription co-activator)

experiments were prepared using the SMART-Seq HT PLUS Kit (Takara #R400748 & #R400749) and multiplexed with the Unique Dual Index Kit 48U (Takara, #R400744), according to manufacturers instructions

Among them, the cytoplasmic region of TNFR1 contains a characteristic death domain (DD) comprised of 80 amino acids, which is utilized to assemble the signaling complex, hence earning it the designation of a death receptor (128)

This peptide is not intended for human or animal consumption or use, and any application outside of controlled laboratory research is prohibited