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249 This activation promotes catabolic processes that generate energy and, concurrently, inhibits mTORC1, halting energy-consuming processes such as gluconeogenesis, lipid synthesis, and protein synthesis

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Nature 2011;476:346-50

1) may reflect, at least in some instances, potential target engagement by omaveloxolone leading to the transient increases in aminotransferases observed in MOXIe Part 2 [16, 20, 22,23,24]