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Following 7 weeks of targeted oral L-carnitine supplementation, the trial patients demonstrated a robust, statistically significant increase in peripheral serotonin alongside a marked reduction in standardized physical fatigue scores

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Moon J.H., Jang E.Y., Shim K.S., Lee J.Y

In 2017, Murata and collaborators reported that serum carnitine level was negatively correlated with severity of constipation in 27 patients

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However, the skin barrier limits the transdermal absorption rate, and simple topical application is difficult to significantly increase the oxidation rate of fatty acids throughout the body or locally