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Many differentially expressed genes (DEGs) related to folate-mediated one-carbon metabolism (FOCM) were found to be enriched in P

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The remaining three casecontrol studies 18,33,37 , while fulfilling most criteria, were vague regarding casecontrol matching and the duration of the exposure period (Supplementary Table S3)

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Importantly, these correlations show co-occurrence rather than causation, indicating that the biochemical and clinical changes develop alongside each other but do not necessarily imply a direct cause-and-effect relationship