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In brief, tip cells, in response to VEGF synthesize platelet-derived growth factor-B (PDGFB), VEGFR-3/Flt-4, VEGFR-2 and Delta-like-4 (DLL4) ligand (Fig

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Randomization was carried out using a minimization approach [Pocock and Simon (1975)] using the following factors: gender, ECOG PS (0 versus 1), response to prior chemotherapy (complete or partial response versus stable disease), history of brain metastases (yes versus no), non-platinum component of induction therapy (docetaxel versus gemcitabine versus paclitaxel), and disease stage (IIIb versus IV)

Elastin is a protein in the connective tissues that is responsible for giving structure to skin and organs

doi:10.1016/j.neubiorev.2004.09.009