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Its primary function is G-actin sequestration TB4 binds monomeric actin with nanomolar affinity, regulates the polymerizable actin pool, and indirectly governs cytoskeletal dynamics during cell migration, wound healing and inflammatory response

They're quickly broken down by peptidases, which are enzymes that cleave peptide bonds

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This method allows for absorption through the oral mucosa, bypassing some digestive breakdown and providing moderate systemic availability

Human CD157 shows predominantly expression within the myelomonocytic lineage, particularly in monocytes, neutrophils, and myeloid stages