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Review Human pineal physiology and functional significance of melatonin.[Front Neuroendocrinol

The first line of evidence supporting a relationship between sleep and neural plasticity comes from that what is being accumulated during wake and reduced during sleep is actually not a molecule, but the overall synaptic strength of many neural circuits, which increases during wake because of learning and needs to be renormalized during sleep to avoid the high cost of plasticity from the increased need for energy and cellular supplies to the saturation of the ability to learn [18]

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