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3458-A METABOLIC BIOMARKER CONSTELLATIONS ALLOW SIMULTANEOUS AND INTEGRATED LIVER AND KIDNEY FUNCTION MONITORING IN CHRONIC LIVER DISEASE Frank Stmmler 1 , Laurence Derain-Dubourg 2 , Sandrine Lemoine 2 , Jeffrey Meeusen 3 , Surendra Dasari 3 , John Lieske 3 , Andrew Robertson 1 and Eric Schiffer 1 , (1)Numares AG, (2)Hospices Civils De Lyon, (3)Mayo Clinic Background: Renal impairment often occurs in liver disease

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Lipid peroxidation scavengers/chain reaction blockers act as radical-trapping antioxidants (RTAs), interrupting the chain amplification of lipid peroxidation and protecting membrane phospholipids, particularly PUFA-containing phospholipids, from oxidative damage

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Samples were de-paraffinized and antigens unmasked by heating in a pressure cooker to 95C and 15 psi for 20 min in Trilogy alkaline solution with EDTA (Cell Marque), followed by 3 min in 90% formic acid