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Glial contributions to neurodegeneration in tauopathies

The "LR3" modification (a substitution at position 3 and an arginine extension) reduces IGF-1 LR3's affinity for IGF-binding proteins (IGFBPs)

the landmark Cho 2001 Nature Neuroscience cabin-crew study linking short recovery to higher cortisol, a smaller right temporal lobe and worse spatial memory