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Source: The potential of GHK as an anti-aging peptide (2020) Claim 2: Intranasal administration bypasses the blood-brain barrier (BBB) to enhance central nervous system (CNS) delivery

Long-term safety studies (beyond 6 months) do not appear to have been conducted for oral glutathione [1]

The decline in T-cell functionality with aging, a widely documented phenomenon, is linked to a reduced efficacy of anti-OX40 immunotherapy in murine models