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In addition, hypertension worsens insulin resistance and disrupts glucose and lipid metabolism, which increases the risk of cardiovascular diseases and T2D in subjects with MetS (Hu and Stampfer, 2005)

Abbreviations AAS: Antibiotic antimycotic solution -GST: Alpha-glutathione s-transferase ALT: Alanine aminotransferase ASGPR1: Asialoglycoprotein receptor 1 CD206: Mannose receptor CD32b: Fc fragment of IgG receptor IIb CYP3A4: Cytochrome P450 3A4 DILI: Drug-induced liver injury DMSO: Dimethyl sulfoxide IL: Interleukin KCs: Kupffer cells LDH: Lactate dehydrogenase LPS: Lipopolysaccharide LSECs: Liver sinusoidal endothelial cells LVX: Levofloxacin mBCI: Monochlorobimane MDMs: Monocyte-derived macrophages PBS: Phosphate buffered saline ROS: Reactive oxygen species RT: Room temperature TNF-: Tumor necrosis factor-alpha TVX: Trovafloxacin VPM: Vascular perfusion medium References Stevens, J

J.LaversanneM.et al (2023)

Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse