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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Rizzo M, Ventrice D, Varone MA, Sidari R, Caridi A

U.HaiyunY.ChunyunW.ZhenkunY.et al (2022)

Decreased A clearance and increased amyloid fibril formation associated with apoE4 probably triggers or exacerbates neurodegeneration and the development of AD

Microglial complement receptor 3 can induce ferroptosis via NADPH oxidase 2 (NOX2) (60), and other NADPH oxidases, including NOX1 (61) and NOX4 (62), are also key contributors to the ferroptotic process

For instance, the number of genes upregulated with age is markedly higher in muscle, lung, and blood than in the brain or the kidney