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Results Preclinical Assessment of Immunogenic Risk for AMG 966 In order to assess the immunogenic risk of AMG 966 and the charge pair mutations ( Supplementary Figure 1 ), an in silico analysis of MHC class II binding was performed using the Immune Epitope Database (IEDB) tool

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This albumin-engineering strategy was also effective when applied with a therapeutic fusion partner, glucagon-like peptide 1 (GLP-1), resulting in a 2-fold increase in plasma half-life and prolonged efficacy in human FcRn transgenic mice

Thus, the enzymatic activity of protein phosphatase 2A (PP2A), a specific phosphatase for -syn, is inhibited, leading to the sustained induction of -Syn p-S129