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Importantly, two research groups demonstrated that Set7/9-mediated methylation of Hif1a under hypoxic conditions increased the proteasomal degradation of Hif1a and hence prevented transactivation of Hif1 target genes [105, 106] (Figure 2B)

Factors that reduce endothelial NO production (increased oxidative stress, changes in NO synthase synthesis) negatively affect endothelial function [73]