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Due to increasing life expectancy and an active, aging population, OA has become the leading cause of joint pain and age-related disability ( th leading cause of disabilities worldwide ( OA is a chronic, low-grade inflammatory, progressive joint disorder characterized by structural damage to one or more joints ( Figure 1 ) ( Figure 1 ) ( Figure 1 The course of OA is highly variable among individuals

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Endoplasmic reticulum stress and Ca 2+ depletion differentially modulate the sterol regulatory protein PCSK9 to control lipid metabolism