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On the other hand, majority of IGF-I actions are mediated through the union of IGF-I to its putative receptor, IGF-IR, a tyrosine kinase that is one of the most potent natural activators of Akt pathway, involving among others: mTOR, MAPK, GSK3, FOXO, HDM2, Grb2 and Shc systems, all of them closely related with cell survival, growth and proliferation [15-17]

The microbiota, which is sterile until birth, begins to develop with birth and is largely influenced by the method of birth, dietary habits, and environmental factors

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Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma

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