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Succinyl-CoA also is required for hemoglobin synthesis.2,4 B12 digestion and absorption requires the adequate synthesis of hydrochloric acid, proteases (enzymes that break down proteins and peptides), and intrinsic factor (a glycoprotein secreted in the stomach)

B12 is water-soluble, meaning excess amounts are safely excreted through urine rather than accumulating in your body, making toxicity extremely rare even at high supplement doses

2019 Jul 30;3(3):e244-e258

Tania Dempsey, a board certified internist at Armonk Integrative Medicine, says vitamin injections and IVs can be essential to patients who have vitamin deficiencies

For life-threatening bleeding, prothrombin complex concentrate (PCC) is administered alongside vitamin K to provide immediate clotting factor replacement